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Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia.

Ines Kaufmann1, Gustav Schelling, Christoph Eisner

  • 1Department of Anesthesiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81366, Munich, Germany.

Rheumatology International
|December 5, 2008
PubMed
Summary

Fibromyalgia patients exhibit reduced expression of adhesion molecules L-selectin (CD62L) and beta(2)-integrin (CD11b/CD18) on immune cells. This may impair immune cell function and pain control in this chronic pain condition.

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Area of Science:

  • Immunology
  • Rheumatology
  • Pain Medicine

Background:

  • Fibromyalgia (FM) is a chronic pain disorder often linked to stress.
  • Stress is known to influence the expression of adhesion molecules.
  • Adhesion molecules play a role in immune cell function and migration.

Purpose of the Study:

  • To investigate the expression of L-selectin (CD62L) and beta(2)-integrin (CD11b/CD18) on polymorphonuclear leukocytes in fibromyalgia patients.
  • To compare these levels with those in healthy controls.

Main Methods:

  • Flow cytometry was used to measure the surface expression of CD62L and CD11b/CD18.
  • Polymorphonuclear leukocytes were isolated from 22 FM patients and age/sex-matched healthy controls.

Main Results:

  • Fibromyalgia patients displayed significantly lower expression of CD62L (p < 0.01) compared to controls.
  • A significant decrease in CD11b/CD18 expression (p < 0.05) was also observed in FM patients.
  • These findings indicate altered immune cell surface markers in fibromyalgia.

Conclusions:

  • Reduced expression of CD62L and CD11b/CD18 on polymorphonuclear leukocytes may impair their migration to inflammatory sites.
  • This could compromise the body's defense against infections and affect pain modulation in fibromyalgia.
  • Further research is warranted to explore the therapeutic implications of these findings.