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Updated: Jun 27, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for
Jianguo Gu1, Yuya Sato, Yoshinobu Kariya
1Division of Regulatory Glycobiology, Tohoku Pharmaceutical University, Sendai Miyagi 981-8558, Japan. jgu@tohoku-pharm.ac.jp
Abstract:
Changes in oligosaccharide structures are associated with numerous physiological and pathological events. E-cadherin-mediated cell-cell adhesion is believed to be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. Here, we focus mainly on a mutual regulation between E-cadherin-mediated cell-cell adhesion and N-acetylglucosaminyltransferase III (GnT-III) expression, and discuss its implications for biological functions.
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