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Peripheral eosinophil count and allergy in patients with coronary artery disease

Ali Esmaeili Nadimi1, Jafar Ahmadi, Mehrnoush Mehrabian

  • 1Department of Internal Medicine, Medical school, RafsanjanUniversity of Medical Sciences and Health Services,Tehran, Iran. swt_f@yahoo.com

Acta Medica Indonesiana
|December 6, 2008
PubMed

Insights

Elevated peripheral blood eosinophil counts were observed in Iranian patients with coronary artery disease (CAD), suggesting a potential role for eosinophils in the development of this condition.

Area of Science:

  • Cardiology
  • Immunology
  • Hematology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • The role of inflammation in CAD pathogenesis is increasingly recognized.
  • Eosinophils, a type of white blood cell, are known for their involvement in allergic reactions and parasitic infections, but their role in cardiovascular diseases is less understood.

Purpose of the Study:

  • To investigate the relationship between peripheral blood eosinophil count and the presence of coronary artery disease (CAD).
  • To explore whether a history of allergy is associated with CAD.
  • To examine eosinophil and neutrophil counts in patients with and without CAD.

Main Methods:

  • A case-control study was conducted with 190 participants (95 with CAD, 95 without CAD) at Ali-ebn-Abitaleb Educational Hospital in Rafsanjan, Iran.
  • Peripheral blood eosinophil count, eosinophil leukocyte ratio, neutrophil count, and neutrophil/leukocyte ratio were measured.
  • Participants' allergy history was recorded.

Main Results:

  • No significant differences in sex or age were found between the CAD and control groups.
  • Mean leukocyte count was significantly higher in the CAD group (8802.6 +/- 253.3) compared to the control group (3813.7 +/- 351.9).
  • Eosinophil percentage was significantly higher in the CAD group (1.43%) than in the control group (0.88%). Allergy history did not differ between groups.

Conclusions:

  • Elevated peripheral blood eosinophil counts were observed in Iranian patients with CAD.
  • These findings suggest that eosinophils may play a role in the pathogenesis of ischemic heart disease.
  • Further research is warranted to elucidate the specific mechanisms by which eosinophils contribute to CAD.
Abstract

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