Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

Teeth

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

Tooth Anatomy

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Phase II Reactions: Methylation Reactions

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Oral health in palliative care: bridging guidance and reality.

British journal of community nursing·2026

Same author

Dental Fear and Anxiety in Children: Association with Individual and Familiar Factors Using Structural Equational Modelling.

International journal of environmental research and public health·2026

Same author

Prevention first - modelling evidence-based prevention with the dental team for children in England.

British dental journal·2026

Same author

Association between dentition status and frailty: Findings from NHANES 2011-2018.

Journal of prosthodontic research·2026

Same author

Optimal design of financial rebates to encourage dental visits.

Journal of dentistry·2025

Same author

Oral cancer risk stratification: A cross-sectional population-based screening study in Northeast India.

International journal of cancer·2025

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Methadone: dental risks and preventive action.

Neil S Nathwani¹, Jennifer E Gallagher

¹King's College London Dental Institute at Guy's, King's College and St Thomas' Hospitals, Department of Oral Health Services Research and Dental Public Health, Oral Health Workforce and Education Research Group, London, UK.

|December 6, 2008

Summary

This summary is machine-generated.

Dentists should be aware that methadone, often prescribed in sugar-based syrup, increases risks of dental decay and erosion. Addressing oral health needs of methadone users is crucial for their overall well-being.

More Related Videos

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Related Experiment Videos

Last Updated: Jun 27, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Area of Science:

Oral health
Pharmacology
Public health

Background:

Sugar-free medications are widely promoted by dentists.
Over 180 sugar-free medicines are available.
Methadone, used for drug rehabilitation, has both sugar-free and sugar-based forms, with the latter being more common.

Purpose of the Study:

To examine methadone content.
To explain prescribing patterns.
To explore multidisciplinary approaches for methadone users' rehabilitation and oral health.
To discuss public health and policy implications of methadone use.

Main Methods:

Literature review.
Examination of methadone content.
Analysis of prescribing patterns.
Discussion of multidisciplinary care strategies.

Main Results:

Methadone users are at increased risk of dental decay and erosion, particularly from sugar-containing methadone syrup.
Lifestyle factors may also contribute to oral health risks.
Dentists often encounter methadone users during dental emergencies.

Conclusions:

Dental practitioners must recognize the heightened oral health risks associated with methadone use.
Addressing the oral health needs of methadone users is integral to their comprehensive rehabilitation and general well-being.