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Bone involvement in pediatric non-Hodgkin's lymphomas.
Sameer Bakhshi1, Preetpaul Singh, Sanjay Thulkar
1Department of Medical Oncology, Dr B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. sambakh@hotmail.com
Hematology (Amsterdam, Netherlands)
|December 6, 2008
Summary
Pediatric non-Hodgkin
Area of Science:
- Pediatric Oncology
- Hematology
- Skeletal Oncology
Background:
- Limited English literature exists on osseous involvement in pediatric non-Hodgkin's lymphoma (NHL).
- Bone involvement in childhood NHL is an understudied area, impacting treatment and prognosis.
Purpose of the Study:
- To investigate the incidence and characteristics of primary and secondary bone involvement in pediatric non-Hodgkin's lymphoma.
- To evaluate treatment outcomes for pediatric patients with skeletal NHL.
Main Methods:
- Retrospective review of 59 pediatric non-Hodgkin's lymphoma cases over 3.5 years.
- Analysis of bone involvement incidence, patient demographics, and treatment responses.
Main Results:
- Eight cases (13.6%) showed bone involvement, predominantly in males (87.5%) with a mean age of 9.9 years.
- Two cases (25%) were primary bone lymphoma, and six (75%) were secondary.
- Chemotherapy was administered to six patients, with 67% achieving complete remission at a median follow-up of 41 months.
- Skeletal involvement was more frequent in relapsed cases than de novo presentations.
Conclusions:
- Pediatric non-Hodgkin's lymphoma can present with significant skeletal involvement.
- Chemotherapy shows promising remission rates in affected children.
- Further research is needed to understand the implications of bone involvement in pediatric NHL, especially in relapsed cases.
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