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The pediatric multiple organ dysfunction syndrome

François Proulx1, Jean Sébastien Joyal, M Michele Mariscalco

  • 1Division of Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Montreal, Canada. fproulx_01@yahoo.ca

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|December 6, 2008
PubMed

Insights

Pediatric multiple organ dysfunction syndrome (MODS) affects critically ill children, with factors like young age and chronic conditions increasing risk. Further research is needed to understand long-term outcomes for pediatric MODS.

Area of Science:

  • Pediatric Critical Care Medicine
  • Immunology
  • Pathophysiology

Background:

  • Critically ill children frequently develop multisystemic manifestations.
  • Pediatric multiple organ dysfunction syndrome (MODS) is a significant concern in pediatric critical care.

Purpose of the Study:

  • To review the epidemiology of pediatric MODS.
  • To summarize current concepts on the pathophysiology of shock, organ dysfunction, and nosocomial infections in children.

Main Methods:

  • MEDLINE-based literature search.
  • Keywords: MODS and child.
  • No language restriction.

Main Results:

  • Young age and chronic health conditions contribute to pediatric MODS.
  • Inflammatory and coagulation pathways lead to capillary leak and ARDS.
  • Neuroendocrine/metabolic responses impair immunity, increasing nosocomial infection risk.

Conclusions:

  • Knowledge of pediatric MODS epidemiology and pathophysiology has increased.
  • Further studies are required to evaluate the long-term outcomes of pediatric MODS.
Abstract

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