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Updated: Jun 27, 2026

Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest
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Published on: May 26, 2023

The pediatric multiple organ dysfunction syndrome.

François Proulx1, Jean Sébastien Joyal, M Michele Mariscalco

  • 1Division of Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Montreal, Canada. fproulx_01@yahoo.ca

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|December 6, 2008
PubMed
Summary
This summary is machine-generated.

Pediatric multiple organ dysfunction syndrome (MODS) affects critically ill children, with factors like young age and chronic conditions increasing risk. Further research is needed to understand long-term outcomes for pediatric MODS.

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Area of Science:

  • Pediatric Critical Care Medicine
  • Immunology
  • Pathophysiology

Background:

  • Critically ill children frequently develop multisystemic manifestations.
  • Pediatric multiple organ dysfunction syndrome (MODS) is a significant concern in pediatric critical care.

Purpose of the Study:

  • To review the epidemiology of pediatric MODS.
  • To summarize current concepts on the pathophysiology of shock, organ dysfunction, and nosocomial infections in children.

Main Methods:

  • MEDLINE-based literature search.
  • Keywords: MODS and child.
  • No language restriction.

Main Results:

  • Young age and chronic health conditions contribute to pediatric MODS.
  • Inflammatory and coagulation pathways lead to capillary leak and ARDS.
  • Neuroendocrine/metabolic responses impair immunity, increasing nosocomial infection risk.

Conclusions:

  • Knowledge of pediatric MODS epidemiology and pathophysiology has increased.
  • Further studies are required to evaluate the long-term outcomes of pediatric MODS.