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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Updated: Jun 27, 2026

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
09:05

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells

Published on: August 7, 2017

Stem cell options for kidney disease.

C Hopkins1, J Li, F Rae

  • 1Institute for Molecular Bioscience, University of Queensland, St. Lucia, Australia.

The Journal of Pathology
|December 6, 2008
PubMed
Summary
This summary is machine-generated.

Chronic kidney disease (CKD) is a growing concern. Regenerative medicine, utilizing stem cells, offers potential new treatments beyond dialysis and transplantation for kidney repair.

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Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Chronic kidney disease (CKD) incidence is rising globally, with limited treatment options currently available.
  • Existing treatments like dialysis and transplantation are invasive and do not fully restore kidney function.
  • Regenerative medicine presents a promising avenue for novel therapeutic strategies in kidney disease.

Purpose of the Study:

  • To review the potential of stem cells and regenerative medicine in treating kidney disease.
  • To assess the role of endogenous and exogenous stem cells in renal repair.
  • To examine the biology of normal renal repair and identify challenges in developing new treatments.

Main Methods:

  • Review of current scientific literature on stem cell therapy and regenerative medicine for kidney disease.
  • Analysis of studies investigating non-renal stem cell sources for renal repair.
  • Examination of research on endogenous renal stem cells and renal repair mechanisms.

Main Results:

  • Non-renal stem cells show potential to influence renal repair processes.
  • Evidence suggests the existence of endogenous renal stem cells capable of contributing to repair.
  • Understanding the biology of normal renal repair is crucial for developing effective regenerative strategies.

Conclusions:

  • Stem cells and regenerative medicine hold significant promise for future kidney disease treatments.
  • Further research is needed to overcome challenges and determine the optimal approach for diverse renal pathologies.
  • A universal solution for all forms of renal disease may not be feasible, necessitating tailored regenerative strategies.