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[Post-hepatitis B, B-D and C cirrhosis].

P Marcellin1

  • 1Service d'hépatologie et INSERM U24, hôpital Beaujon, Clichy.

La Revue Du Praticien
|May 1, 1991
PubMed
Summary

Hepatitis B, C, and D viruses cause chronic hepatitis, leading to post-hepatitic cirrhosis over decades. Treatment includes antiviral therapy and liver transplantation, with vaccination crucial for prevention.

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Area of Science:

  • Hepatology
  • Virology
  • Oncology

Context:

  • Hepatitis B virus (HBV), hepatitis D virus (HDV), and hepatitis C virus (HCV) are primary causes of post-hepatitic cirrhosis.
  • These viruses induce chronic active hepatitis, progressing to cirrhosis over 5-30 years.
  • Post-hepatitic cirrhosis accounts for over 90% of chronic hepatitis in France, presenting unique complications.

Purpose:

  • To outline the viral etiologies of post-hepatitic cirrhosis.
  • To describe the clinical course and complications, including hepatocellular carcinoma.
  • To review current treatment options and preventive strategies.

Summary:

  • Hepatitis B, C, and D viruses cause chronic active hepatitis, leading to post-hepatitic cirrhosis.
  • Complications include liver insufficiency, portal hypertension, and a high risk of hepatocellular carcinoma.
  • Available treatments are antiviral therapy (interferon alpha) and liver transplantation, with vaccination against HBV being key for prevention.

Impact:

  • Highlights the significant role of HBV, HCV, and HDV in cirrhosis development.
  • Emphasizes the increased risk of hepatocellular carcinoma in post-hepatitic cirrhosis.
  • Stresses the importance of timely antiviral treatment and vaccination for at-risk populations.

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