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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
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[Immunology and BCG therapeutics]

Manuel Anastacio Sánchez Olivas1, Martha Patricia Valencia Zavala, José Montes Montes

  • 1Servicio de alergia e inmunología clínica, Hospital General de México, SS.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|December 9, 2008
PubMed

The importance in the study of bacillus of Calmette-Guérin or BCG is related to several functions derived from its influence on the immunological system, between which it is found the prevention of the dissemination of the tubercular bacillus, its utilization as immunomodulator in some oncologic illness (as vesical cancer) in order to avoid post-surgical recidiva or in some forms of immunotherapy, as the cytokine (interferon alpha and interleukin-2); in addition, BCG vaccine is supplied like an immunomodulator in treatment of melanoma. It is important to continue with the study of the BCG strains for its great utility in the treatment of various diseases, example of the previous is the Tice strain, which is used in the superficial cancer of bladder and in the production of new and more powerful vaccines for the protection of tuberculosis.

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