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Updated: Jun 27, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Morphological modification of female bladder after prolonged use of soy-based diets
Tatiane da Silva Faria1, Lavínia Leal Soares, Jorge L Medeiros
1Urogenital Research Unit-UERJ, Biomedical Center, State University of Rio de Janeiro, Av. 28 de Setembro, 87-fundos-FCM-terreo, 20551-030 Rio de Janeiro, RJ, Brazil.
Objectives:
The aim of this study was to compare the effects of a prolonged use of organic and transgenic soy upon the lipid profile and the collagen/muscle ratio of the detrusor muscle of the bladder.
Methods:
Wistar rats were fed three different diets from weaning until sacrifice (15 months old): control group (CG) casein-based diet; organic soy group (OSG) organic soy-based diet; genetically modified soy group (GMSG) transgenic soy-based diet.
Results:
There was no difference in the food consumption or in the diet isoflavone components among the groups. Comparing to CG, both OSG and GMSG groups presented a significant (p<0.05) reduction in the body weight, triglycerides, cholesterol and the smooth muscle of the detrusor and a significant (p<0.05) increase of collagen fibers number of the detrusor muscle.
Conclusions:
These findings call into question that, the prolonged use of soy-based diets can be deleterious to the bladder by altering the collagen/muscle ratio what can cause bladder dysfunctions similar with that occurring during menopause.
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