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Updated: Jun 27, 2026
07:32
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
Role of bone in osteoarthritis pathogenesis
1The Hospital for Special Surgery, Weill College of Medicine of Cornell University, 535 East 70th Street, New York, NY 10021, USA. goldrings@hss.edu
The Medical Clinics of North America
|December 9, 2008
Summary
Osteoarthritis (OA) affects more than just cartilage, impacting ligaments, tendons, and bone. This review details the skeletal changes in OA and their underlying causes.
Area of Science:
- Orthopedics and Rheumatology
- Skeletal Biology
Background:
- Osteoarthritis (OA) management often prioritizes articular cartilage.
- Joint structures beyond cartilage, including ligaments, tendons, capsule, synovium, and bone, are significantly altered in OA.
Purpose of the Study:
- To review the specific skeletal features of osteoarthritis.
- To explore the proposed mechanisms driving skeletal pathogenesis in OA.
Main Methods:
- Literature review focusing on OA pathogenesis.
- Analysis of structural and functional changes in joint components.
Main Results:
- OA involves widespread structural and functional alterations across all joint components.
- Periarticular bone exhibits distinct pathological changes during OA progression.
Conclusions:
- A comprehensive understanding of OA requires considering all affected joint tissues, particularly skeletal elements.
- Investigating skeletal pathogenesis is crucial for developing effective OA diagnostics and therapeutics.
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