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Chronic plaque psoriasis is associated with increased arterial stiffness

Paolo Gisondi1, Francesco Fantin, Micol Del Giglio

  • 1Section of Dermatology and Venereology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy. paolo.gisondi@univr.it

Dermatology (Basel, Switzerland)
|December 9, 2008
PubMed

Insights

Patients with moderate to severe chronic plaque psoriasis exhibit increased arterial stiffness, a cardiovascular risk factor. Longer psoriasis duration correlates with this stiffness, suggesting a link between skin disease and vascular health.

Area of Science:

  • Cardiovascular Health
  • Dermatology
  • Vascular Biology

Background:

  • Moderate to severe chronic plaque psoriasis is linked to higher rates of cardiovascular risk factors and atherosclerosis.
  • Arterial stiffness, a marker of endothelial dysfunction, independently predicts cardiovascular events.

Purpose of the Study:

  • To determine if chronic plaque psoriasis is associated with elevated arterial stiffness.

Main Methods:

  • A cross-sectional study compared 39 adult patients with moderate to severe chronic plaque psoriasis to 38 controls with other skin conditions.
  • Arterial stiffness was measured using carotid-femoral and carotid-radial pulse wave velocity (PWVcf, PWVcr).

Main Results:

  • Carotid-femoral pulse wave velocity (PWVcf) was significantly higher in psoriasis patients (8.88 +/- 1.96 m/s) versus controls (7.57 +/- 1.34 m/s; p = 0.001).
  • This difference remained significant after adjusting for age, gender, smoking, hypertension, and BMI (p = 0.03).
  • A positive correlation was observed between PWVcf and psoriasis duration (r = 0.58; p = 0.0001), but not disease severity.

Conclusions:

  • Moderate to severe chronic plaque psoriasis may be independently associated with increased arterial stiffness.
  • Psoriasis duration is a potential risk factor for developing arterial stiffness and atherosclerosis.
Abstract

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