Related Experiment Video
Updated: Jun 7, 2026
07:28
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
Steroids and extubation: the potential for clinical trials
1Shriners Hospitals for Children, Northern California, USA.
Summary
Extubation of patients with inhalation injuries is challenging. Steroids and noninvasive positive pressure ventilation are potential adjuncts to aid in the removal of mechanical ventilation for burn patients.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Burn Surgery
Background:
- Airway management, including intubation and mechanical ventilation, is crucial for patients with inhalation injuries.
- The primary objective following intubation is the eventual weaning from mechanical ventilation.
- Extubation in burn patients with inhalation injuries presents unique challenges.
Purpose of the Study:
- To explore adjuncts that facilitate extubation in burn patients with inhalation injuries.
- To evaluate the potential benefits of steroids in the extubation process.
- To assess the utility of noninvasive positive pressure ventilation as an extubation aid.
Main Methods:
- This section reviews two distinct approaches to assist with extubation.
- The first approach involves the use of steroids.
- The second approach examines noninvasive positive pressure ventilation.
Main Results:
- The abstract does not contain specific results, but introduces two potential methods for extubation.
- Steroids may help manage inflammation and improve respiratory function.
- Noninvasive positive pressure ventilation might reduce the work of breathing.
Conclusions:
- Extubation from mechanical ventilation is a critical but difficult step for burn patients with inhalation injuries.
- Steroids and noninvasive positive pressure ventilation are presented as promising adjunctive therapies.
- Further investigation into these methods is warranted to optimize patient recovery.
Related Concept Videos
01:16Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
01:11Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
01:24Endotracheal Tube Extubation
Endotracheal tube extubation is a critical procedure in weaning patients from mechanical ventilation. It involves physically removing the oral or nasal endotracheal (ET) tube, marking the final step in liberating a patient from ventilatory support.
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals.
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals.