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Related Concept Videos

Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
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Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...

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Application of Hemostatic Devices in Laparoscopic Hepatectomy
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Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

Hepatic adenomatosis.

Wesley O C Greaves1, Baishali Bhattacharya

  • 1Department of Pathology, Rhode Island Hospital and Brown University, Providence, RI 02903, USA. wgreaves@lifespan.org

Archives of Pathology & Laboratory Medicine
|December 9, 2008
PubMed
Summary
This summary is machine-generated.

Hepatic adenomatosis, defined as over 10 liver adenomas, presents risks like malignancy. Recent findings link it to hepatocyte nuclear factor 1alpha mutations, impacting patient management strategies.

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Oncology

Background:

  • Hepatic adenomatosis is characterized by multiple liver adenomas (>10) in normal liver parenchyma.
  • It is considered distinct from solitary hepatic adenomas often linked to oral contraceptive use in young women.
  • Despite being benign, it carries risks of malignant transformation and life-threatening hemorrhage.

Purpose of the Study:

  • To review the current understanding of hepatic adenomatosis.
  • To discuss its etiology, natural history, and potential complications.
  • To explore current and emerging management strategies.

Main Methods:

  • Literature review of hepatic adenomatosis.
  • Analysis of reported cases and etiological factors.
  • Discussion of management options including surgical intervention and genetic counseling.

Main Results:

  • Hepatic adenomatosis is a distinct entity with potential for severe complications.
  • Germline mutations in hepatocyte nuclear factor 1alpha are implicated in a subset of cases.
  • Surgical removal of large lesions can alleviate symptoms and reduce complication risks.

Conclusions:

  • Hepatic adenomatosis requires careful consideration due to associated risks.
  • Genetic mutations may play a role, highlighting the importance of genetic counseling.
  • Management strategies are evolving, with surgery and genetic counseling being key components.