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Acanthosis nigricans: a practical approach to evaluation and management
Steven P Higgins1, Michael Freemark, Neil S Prose
1Division of Dermatology, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA. steven.higgins@alumni.duke.edu
Abstract:
Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize acanthosis nigricans; it heralds disorders ranging from endocrinologic disturbances to malignancy. In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management.
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