Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Hyperthyroidism I: Introduction

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Hypothyroidism II: Pathophysiology

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Regional patterns of molecular sensitization to dust mites and pollens in a Portuguese pediatric population: a multicentric study.

Allergologia et immunopathologia·2026

Same author

Juvenile Xanthogranuloma: A Visual Clinical Diagnosis.

Cureus·2025

Same author

Hoagland Sign-A Common Diagnosis Preceded by an Uncommon Sign.

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners·2025

Same author

Neonatal intraoral papulovesicular lesions: A rare manifestation of a common condition.

Anales de pediatria·2025

Same author

[Kaposi Sarcoma: Between the Skin and the World].

Acta medica portuguesa·2025

Same author

Correction: Child-mother relationships and childhood dietary patterns in the Iberian Peninsula uncovered by Bayesian isotopic approaches.

Scientific reports·2025

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Sweet syndrome associated with Hashimoto thyroiditis.

Sandra Medeiros¹, Raquel Santos, Victor Carneiro

¹Dermatology Department, Hospital do Divino Espírito Santo, Ponta Delgada. sandradmedeiros@clix.pt

Dermatology Online Journal

|December 9, 2008

Summary

This summary is machine-generated.

Sweet syndrome, a skin condition, may be linked to Hashimoto thyroiditis through the role of cytokines. Understanding this connection could offer new insights into both autoimmune diseases.

More Related Videos

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Area of Science:

Dermatology
Endocrinology
Immunology

Background:

Sweet syndrome, a neutrophilic dermatosis, was first described by R. D. Sweet in 1964.
Hashimoto thyroiditis is a common autoimmune disorder affecting the thyroid gland.

Observation:

The simultaneous occurrence of Sweet syndrome and Hashimoto thyroiditis was first reported by Nakayama et al. in 1993.
Cytokines are implicated in the pathogenesis of various inflammatory and autoimmune conditions.

Findings:

Cytokines may play a crucial role in the development of both Sweet syndrome and Hashimoto thyroiditis.
This cytokine-mediated pathway could represent a shared mechanism linking these two distinct conditions.

Implications:

Further research into cytokine signaling may elucidate the relationship between Sweet syndrome and Hashimoto thyroiditis.
Identifying common pathways could lead to novel therapeutic strategies for patients with co-occurring conditions.