Related Experiment Video
Updated: Jun 27, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Hypodontia: an epidemiologic study of American black and white people
Edward F Harris1, Larkin L Clark
1Department of Orthodontics, College of Dentistry, University of Tennessee, Memphis, TN 38163, USA. Eharris@utmem.edu
Introduction:
There are numerous epidemiologic studies of hypodontia, but most focus on white populations that, because of small teeth and slow development, might not represent the status of other peoples. The purpose of this study was to contrast the distributions of hypodontia in an adolescent sample of American blacks (n=600) with a comparable sample of whites (n=1100).
Methods:
Panoramic radiographs of 1700 unrelated adolescents between 12 and 18 years were scrutinized for hypodontia. Those with syndromes and major genes contributing to congenital absence were omitted.
Results:
The prevalence of people with missing teeth is significantly lower in blacks (11%) than in whites (27%), as is the number of missing teeth per person. When all tooth types were combined for a summary value, the frequency of missing teeth in whites (1.5% of the expected 32 teeth per person) was significantly higher than in blacks (0.6%), with an odds ratio of 2.52 (95% confidence limits [CL]: 2.07, 3.08). Differences between black and white people are disproportionately large where hypodontia is most common, notably in 2 tooth types: (1) the difference is statistically significant for third molars, with the odds ratio 3.18 higher in whites (CL: 2.43, 4.17) for all quadrants combined, and (2) for second premolars (combining all quadrants), whites are 1.75 times more likely to exhibit congenital absence (CL: 1.06, 2.90). In contrast, significant sex differences were found only for the third molars (absence more common in females), and the sex differences were greater in whites than in blacks.
Conclusions:
Extrapolations from the literature, based largely of studies of white subjects, do not readily apply to American blacks or, potentially, to other racial groups.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Bias in Epidemiological Studies
Development of the Oral Microbiota
Ethics in Research
Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
