Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Monolithic manufacturing of an electrically addressable quasi-suspended nanophotonic aperture.

Nature nanotechnology·2026

Same author

Protein loops are major contributors to DNA strand separation and high-fidelity substrate recognition for DNA methyltransferase CcrM.

The Journal of biological chemistry·2026

Same author

Cyclopeptide-Based Fluorescent Conjugates for Monitoring Prefibrillar Aβ Nanostructures.

Journal of medicinal chemistry·2026

Same author

Mechanisms of DNA methyltransferase 3A1-mediated DNA methylation of nucleosomes.

The Journal of biological chemistry·2026

Same author

Super-resolution structured illumination microscopy of cellular nanopores using near-infrared fluorescent probes.

Optics express·2026

Same author

Offsetting ROS-Mediated Arrest of Endothelial Fenestration Dynamics Permits Long-Term Optical Super-Resolution Imaging Validated by AFM.

ACS applied materials & interfaces·2026

Same journal

Decoding Galectin-Glycan Recognition with <sup>19</sup>F-Tagged Lectins: from Simple Glycans to the Cellular Glycocalyx.

Journal of the American Chemical Society·2026

Same journal

Open- and Closed-Shell Roles of Sensitizer and Annihilator in Pseudo-Single Component Mixtures for Upconversion.

Journal of the American Chemical Society·2026

Same journal

Pressure-Induced Superconductivity at 15 K in van-der-Waals Ferroelectric CuInP<sub>2</sub>S<sub>6</sub>.

Journal of the American Chemical Society·2026

Same journal

Carbene Analogues of Group 15: Reduction of s-Hydrindacene-Based Chloropnictogenium Ions To Access an Antimony Hydride Monocation and a Trinuclear Bismuth Dication.

Journal of the American Chemical Society·2026

Same journal

Chiral-Ligand-Modulated Nickel-Catalyzed Stereoselective Radical Migratory C2-Arylation of Carbohydrates.

Journal of the American Chemical Society·2026

Same journal

Coordination-Constraint-Driven Enhanced Chirality Induction in Perovskite Quantum Dot Solids.

Journal of the American Chemical Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 14, 2026

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

Rapid, solution-based characterization of optimized SERS nanoparticle substrates.

Ted A Laurence¹, Gary Braun, Chad Talley

¹Chemistry, Materials, Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

Journal of the American Chemical Society

|December 10, 2008

Summary

This summary is machine-generated.

This study uses confocal laser spectroscopy to rapidly analyze individual metal nanoparticles in solution. Specifically designed nanostructures show better uniformity than random aggregates, aiding nanoparticle development.

More Related Videos

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Related Experiment Videos

Last Updated: Jan 14, 2026

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Area of Science:

Nanotechnology
Materials Science
Physical Chemistry

Background:

Characterizing individual nanoparticles in solution is crucial for developing advanced materials.
Existing methods for assessing nanoparticle uniformity can be time-consuming and lack precision.
Optimizing nanoparticle synthesis requires rapid feedback on structural integrity and monodispersity.

Purpose of the Study:

To develop a rapid optical method for characterizing individual metal nanoparticles in colloidal solution.
To assess the monodispersity of specifically designed nanostructures (hollow gold nanospheres, silver nanoparticle dimers) compared to random aggregates.
To guide nanoparticle engineering and optimization through precise characterization.

Main Methods:

Utilizing confocal laser spectroscopy for high-throughput analysis of freely diffusing nanoparticles.
Measuring ratios of Rayleigh and Raman scattering responses from individual nanoparticles.
Determining rotational diffusion timescales of individual nanoparticles in solution.

Main Results:

Demonstrated rapid optical characterization of large numbers of individual metal nanoparticles.
Hollow gold nanospheres and solid silver nanoparticle dimers exhibited significantly higher monodispersity.
Designed nanostructures showed superior uniformity compared to randomly aggregated gold and silver nanoparticles.

Conclusions:

Confocal laser spectroscopy is an effective tool for rapid, high-throughput nanoparticle characterization.
Specifically designed nanostructures offer enhanced monodispersity crucial for controlled applications.
This technique facilitates efficient nanoparticle engineering and optimization for tailored properties.