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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.

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Related Experiment Video

Updated: Jun 27, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

Defining protein interactions that regulate disease progression.

Racha Al-Khoury1, Benoit Coulombe

  • 1Institut de recherches cliniques de Montréal, Montréal (Québec), Canada.

Expert Opinion on Therapeutic Targets
|December 10, 2008
PubMed
Summary
This summary is machine-generated.

Understanding protein-protein interactions is key to cellular function and disease, like cancer. Studying these networks helps develop new drugs by targeting disease-related interactions.

More Related Videos

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

Related Experiment Videos

Last Updated: Jun 27, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Biology
  • Pharmacology

Background:

  • Protein-protein interactions (PPIs) are fundamental to cellular processes and function.
  • Aberrant PPIs are implicated in diseases, including cancer, highlighting the need for research.
  • Understanding normal and disease-related PPI networks is crucial for therapeutic development.

Purpose of the Study:

  • To review common methods for studying protein-protein interactions.
  • To discuss the progression of systematic characterization of protein interaction networks.
  • To highlight therapeutic strategies targeting disease-related PPIs.

Main Methods:

  • Review of established techniques for analyzing protein-protein interactions.
  • Discussion of advancements in mapping protein interaction networks.
  • Case studies of small molecule interventions in disease-related PPIs.

Main Results:

  • Commonly used approaches for studying PPIs are presented.
  • The trajectory of systematic protein interaction network characterization is outlined.
  • Successful examples of modulating disease-associated PPIs with small molecules are provided.

Conclusions:

  • The study of PPIs is vital for elucidating cellular mechanisms and disease pathologies.
  • Systematic network analysis offers powerful insights into biological systems.
  • Targeting PPIs with small molecules represents a promising therapeutic avenue for various diseases.