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Updated: Jun 27, 2026
05:46
A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Exhaled nitric oxide in pediatric asthma.
1Section of Allergy, Asthma, and Immunology, Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA. cdinakar@cmh.edu
Current Allergy and Asthma Reports
|December 10, 2008
Summary
Measuring exhaled nitric oxide offers a simple, noninvasive test for airway inflammation in asthma. This method helps identify patients responsive to steroids and monitor treatment effectiveness.
Area of Science:
- Clinical Medicine
- Pulmonology
- Biomarkers
Background:
- Airway inflammation is central to asthma pathogenesis.
- Previously, assessing airway inflammation in clinical settings was challenging.
- Exhaled nitric oxide (FeNO) measurement offers a novel approach.
Purpose of the Study:
- To evaluate exhaled nitric oxide as a noninvasive marker for airway inflammation in asthma.
- To assess FeNO's utility in identifying steroid-responsive asthma.
- To explore FeNO's role in monitoring steroid therapy.
Main Methods:
- Noninvasive point-of-service testing of exhaled nitric oxide.
- Utilizing standardized methodology and handheld analyzers.
- Storing serial measurements using individualized patient cards.
Main Results:
- Exhaled nitric oxide is a reproducible measure of airway inflammation.
- FeNO serves as an excellent surrogate marker for steroid-responsive eosinophilic airway inflammation.
- Technological advancements facilitate clinical application.
Conclusions:
- FeNO measurement is a valuable, noninvasive tool for asthma assessment.
- It aids in identifying steroid-sensitive asthma patients.
- FeNO facilitates monitoring treatment response and dose titration.
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