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Updated: Jun 27, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
Published on: May 23, 2025
Solitary vertebral metastasis
Daniel M Sciubba1, Trang Nguyen, Ziya L Gokaslan
1Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA. dsciubb1@jhmi.edu
Abstract:
As survival time increases for many cancers, it is likely that the incidence and prevalence of spinal metastases will increase also. Given that most patients first present with solitary lesions in the spine, proper initial diagnosis and management are of paramount importance in minimizing pain, improving neurologic function, and potentially lengthening survival. Although pain control and standard radiation are still used, spinal stereotactic radiosurgery, vertebroplasty and kyphoplasty, and spinal cord decompression and fusion are now consistently used in aggressive management and offer exciting preliminary results.
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