Related Experiment Video
Updated: Jun 27, 2026
09:43
Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
Diffuse intracranial oligodendroglioma in a cow.
S Kleinschmidt1, K Herzog, L Krüger
1Department of Pathology, Germany.
Journal of Comparative Pathology
|December 10, 2008
Summary
This study details a rare diffuse, cerebral oligodendroglioma in an adult cow. The tumor infiltrated the brain and meninges, showing unique immunohistochemical markers.
Area of Science:
- Veterinary Neurology
- Comparative Pathology
- Neuro-oncology
Background:
- Oligodendrogliomas are rare in domestic animals, with limited reports in cattle.
- Understanding brain tumors in cattle is crucial for animal health and comparative studies.
Observation:
- A case of a diffuse, cerebral oligodendroglioma in an adult cow is presented.
- The tumor spanned the metencephalon to the telencephalon, involving the meninges.
Findings:
- Immunohistochemistry revealed tumor cells negative for glial fibrillary acid protein, neuron-specific enolase, myelin basic protein, and synaptophysin.
- Partial positivity for S-100 and tau protein was observed, with a lack of a specific tumor antigen.
- This represents the first documented instance of a diffuse, cerebral oligodendroglioma in a cow.
Implications:
- This case expands the understanding of neuropathology and tumor types in bovine species.
- Findings contribute to the comparative oncology database, aiding in the diagnosis and research of brain tumors across species.
- Highlights the importance of detailed immunohistochemical analysis for accurate tumor classification in veterinary neurology.
