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Related Experiment Video

Updated: Jun 27, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

Restoring patency to central venous access devices.

Cynthia Cummings-Winfield1, Tayreez Mushani-Kanji

  • 1Nursing Research and Professional Practice Development, Cross Cancer Institute, Edmonton, Canada. cindywin@cancerboard.ab.ca

Clinical Journal of Oncology Nursing
|December 10, 2008
PubMed
Summary

Standardized guidelines for managing central venous access device (CVAD) occlusions in cancer patients are needed. Evidence-based recommendations for using thrombolytic agents can safely restore CVAD patency, improving patient quality of life.

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Last Updated: Jun 27, 2026

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Area of Science:

  • Oncology Nursing
  • Vascular Access Device Management

Background:

  • Inconsistent practices exist in managing central venous access device (CVAD) occlusions among Canadian cancer treatment centers.
  • Thrombotic occlusions are a common complication affecting CVAD functionality.

Purpose of the Study:

  • To develop evidence-based, standardized guidelines for managing thrombotic CVAD occlusions.
  • To provide consensus recommendations for the use of thrombolytic agents in restoring CVAD patency.

Main Methods:

  • A systematic literature review of CVAD complications (1997-2007) was conducted using PubMed.
  • Institutional and published protocols for thrombolytic treatment of occluded CVADs were compared.
  • An Oncology Nursing Advisory Board convened to discuss current practices and formulate recommendations.

Main Results:

  • Restoring CVAD patency with thrombolytics is a safe, effective, and cost-effective alternative to device replacement.
  • Standardized, evidence-based guidelines are advocated to address practice inconsistencies.

Conclusions:

  • The presented treatment algorithm offers consensus recommendations for managing thrombotic CVAD occlusions in adult cancer patients.
  • Implementing standardized guidelines can improve patient outcomes and quality of life by maintaining CVAD function.