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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

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Published on: July 24, 2020

Modeling the eye's optical system by ocular wavefront tomography.

Xin Wei¹, Larry Thibos

¹School of Optometry, Indiana University, 800 East Atwater Ave., Bloomington, IN 47405, USA. weix@indiana.edu

|December 10, 2008

Summary

Ocular wavefront tomography (OWT) creates customized eye models using aberration maps. This robust method accurately reconstructs eye optics for personalized vision correction.

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Area of Science:

Ophthalmology
Optical Engineering
Biomedical Imaging

Background:

Ocular wavefront tomography (OWT) analyzes wavefront aberration maps from multiple lines-of-sight (LoS).
A key goal is to develop patient-specific schematic eye models that are both anatomically accurate and functionally equivalent across a wide field of view.

Purpose of the Study:

To implement and validate a method for constructing customized ocular optical models using OWT.
To demonstrate the feasibility of creating anatomically and functionally accurate eye models over a large field of view.

Main Methods:

Utilized wavefront aberration maps from multiple LoS as design targets.
Configured a generic, multi-surface eye model, optimizing its aberrations to match measured data.
Constrained the model with gross anatomical dimensions and validated using a physical eye model and a mathematical myopia model.

Main Results:

The OWT algorithm successfully predicted the structure of a physical model eye.
An optimized five-surface model accurately replicated the aberrations of a GRIN myopia model.
The discrepancies in aberrations were minimal (0.05 microns RMS and 0.2 microns RMS for the two cases).

Conclusions:

The developed OWT implementation is a valid, feasible, and robust technique.
It enables the construction of optical eye models that closely mimic individual anatomy and function over a wide field of view.