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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

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Updated: Jun 27, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

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Published on: August 4, 2019

TP53 codon 72 polymorphism in adult soft tissue sarcomas.

P S R Almeida1, W J Manoel, A A S Reis

  • 1Departamento de Biologia, Programa de Mestrado em Genética, Universidade Católica de Goiás, Goiânia, GO, Brasil.

Genetics and Molecular Research : GMR
|December 11, 2008
PubMed
Summary

TP53 codon 72 polymorphism (Arg72Pro) did not significantly impact soft tissue sarcoma (STS) susceptibility or prognosis. While the Pro/Pro variant showed a trend towards reduced survival, this finding was not statistically significant in STS patients.

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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Soft tissue sarcomas (STS) are rare neoplasms of mesodermal origin, posing significant management challenges.
  • The TP53 codon 72 polymorphism (Arg72Pro) influences the p53 protein, with potential roles in cancer risk and prognosis.
  • Previous studies suggest a link between TP53 codon 72 variants and various cancers, necessitating investigation in STS.

Purpose of the Study:

  • To investigate the association between TP53 codon 72 polymorphism (Arg72Pro) and susceptibility to soft tissue sarcomas.
  • To evaluate the impact of Arg72Pro genotypes on the clinical outcome and survival of STS patients.

Main Methods:

  • Genotyping of the TP53 Arg72Pro polymorphism using polymerase chain reaction in 100 STS patients.
  • Comparison of genotype frequencies between STS patients and 85 healthy controls.
  • Analysis of correlations between polymorphic genotypes, clinicopathological factors, and patient survival.

Main Results:

  • No significant difference in genotypic frequencies was observed between STS patients and healthy controls.
  • TP53 codon 72 variants were not significantly associated with STS patient demographics, tumor characteristics, or metastasis.
  • Five-year overall survival for STS was 48%, significantly influenced by tumor grade, stage, and metastasis, but not by Arg72Pro genotype.

Conclusions:

  • The TP53 Arg72Pro polymorphism is not a significant factor for susceptibility or prognosis in soft tissue sarcomas.
  • Tumor grade, clinical stage, and metastasis remain critical prognostic indicators for STS.
  • Further research may be needed to explore other genetic factors influencing STS outcomes.