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Related Experiment Video

Updated: Jun 27, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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[Specular microscopy and pseudoexfoliative syndrome].

Eliza Tebeanu1, C Stefan

  • 1Spitalul clinic de urgenţă Militar Central "Dr. Carol Davila", Bucureşti. elizatebeanu@yahoo.com

Oftalmologia (Bucharest, Romania : 1990)
|December 11, 2008
PubMed
Summary

Pseudoexfoliative material stresses corneal endothelial cells, causing degeneration. This condition, more common in older women, significantly reduces endothelial cell density, especially when glaucoma is present.

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[Changes in corneal thickness in glaucoma].

Oftalmologia (Bucharest, Romania : 1990)·2013

Area of Science:

  • Ophthalmology
  • Corneal Science
  • Cell Biology

Context:

  • Pseudoexfoliative material production causes stress to corneal endothelial cells.
  • This stress leads to secondary degeneration and corneal decompensation.
  • The condition is typically bilateral, asymmetrical, and slowly progressive.

Purpose:

  • To describe the impact of pseudoexfoliative material on corneal endothelium.
  • To highlight the association between pseudoexfoliative keratopathy and glaucoma.
  • To detail the resulting endothelial cell density decrease.

Summary:

  • Pseudoexfoliative keratopathy is a corneal endotheliopathy more frequent in women over 70.
  • Specular microscopy reveals a severe decrease in endothelial cell density.
  • Associated glaucoma and high intraocular pressure exacerbate endothelial dysfunction, causing up to 35% cell density loss.

Impact:

  • Provides insight into corneal decompensation mechanisms in pseudoexfoliation.
  • Emphasizes the detrimental effect of glaucoma on pseudoexfoliative keratopathy.
  • Informs clinical understanding and management of this condition.

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