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Updated: Jun 27, 2026
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An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry
Published on: May 13, 2019
Statistical evaluation of the in vivo micronucleus assay
Ludwig A Hothorn1, Daniel Gerhard
1Institute of Biostatistics, Leibniz University, Herrenhauser Str. 2, 30419 Hannover, Germany. hothorn@biostat.uni-hannover.de
Archives of Toxicology
|December 11, 2008
Abstract:
The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.
