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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Jugular Venous Pressure (JVP) Measurement
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Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Vascular disease in scleroderma.

Fredrick M Wigley1

  • 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. fwig@jhmi.edu

Clinical Reviews in Allergy & Immunology
|December 11, 2008
PubMed
Summary
This summary is machine-generated.

Scleroderma involves significant vascular disease, not just tissue fibrosis. Understanding endothelial cell injury and vascular remodeling offers new therapeutic targets for this complex condition.

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Area of Science:

  • Rheumatology
  • Vascular Biology
  • Immunology

Background:

  • Scleroderma is traditionally viewed as a fibrosing condition.
  • Emerging evidence highlights the critical role of vascular disease in scleroderma pathogenesis and tissue damage.

Purpose of the Study:

  • To review the evidence for the causes and consequences of vascular disease in scleroderma.
  • To explore the complex interactions contributing to vascular dysfunction in scleroderma.

Main Methods:

  • Literature review of studies investigating scleroderma vascular disease.
  • Analysis of proposed mechanisms including endothelial cell injury and immune-mediated factors.

Main Results:

  • Endothelial cell injury (from infection, autoimmunity, ischemia-reperfusion) is implicated in scleroderma vascular disease.
  • Vascular damage produces biomarkers that may predict clinical outcomes.
  • Complex interactions of cellular and matrix factors drive vascular reactivity, remodeling, and occlusion.

Conclusions:

  • Vascular disease is fundamental to scleroderma pathogenesis.
  • Understanding these mechanisms supports the development of targeted therapies for scleroderma.