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Development of a Virtual Reality Assessment of Everyday Living Skills

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Published on: April 23, 2014

[25 years antipsychotics: back to the future?].

D Denys¹, L de Haan

¹Afdeling Psychiatrie, Academisch Medisch Centrum/Universiteit van Amsterdam, Amsterdam. d.denys@amc.nl

Tijdschrift Voor Psychiatrie

|December 11, 2008

Summary

Antipsychotic medications revolutionized psychiatry 50 years ago. However, newer atypical antipsychotics have shown limited improvement in treating psychosis, despite research efforts.

Area of Science:

Psychiatry
Pharmacology
Neuroscience

Context:

The advent of antipsychotics 50 years ago transformed psychiatric care, enabling mass deinstitutionalization of patients with psychosis.
Recent decades have seen the introduction of atypical antipsychotics, aiming for improved efficacy and reduced side effects.

Purpose:

To evaluate the clinical impact of atypical antipsychotics compared to their predecessors.
To assess the progress in pharmacological research for novel antipsychotic drug development.

Summary:

While typical antipsychotics revolutionized psychiatric treatment and deinstitutionalization, atypical antipsychotics introduced over the last 25 years have not significantly advanced psychosis management.
Pharmacological research has focused on developing drugs with comparable efficacy to typical antipsychotics but with fewer extra-pyramidal side effects and better outcomes for negative symptoms and cognitive deficits.

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Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Despite some patient benefits, atypical antipsychotics have largely failed to meet the high expectations set for them in treating psychosis.

Impact:

The findings suggest a need for reassessment of current antipsychotic drug development strategies.
This review highlights the persistent challenges in effectively treating psychosis, particularly negative symptoms and cognitive impairments.
Further research is warranted to explore novel therapeutic targets and approaches beyond current antipsychotic paradigms.