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Updated: Jun 27, 2026

Green Synthesis of Quinoline-Based Ionic Liquid
Published on: September 27, 2024
L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid
Xiu-hong Liu1, Ji-cai Fan, Yang Liu
1Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Abstract:
The effect of L-proline as a promoter on the condensation reaction of salicylaldehyde or its derivatives with ethyl acetoacetate in neutral ionic liquid [emim]BF4 was studied. All reactions were carried out under mild reaction conditions and achieved high yields. Moreover, the ionic liquid containing L-proline could be recycled and reused for several times without noticeably decreasing in productivity. The results show that the L-proline-[emim]BF4 system has a potential in contribution to the development of environmentally friendly and inexpensive processes in organic syntheses.
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