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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
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Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
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Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Updated: Jun 27, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Phototherapy in childhood.

Sibel Ersoy-Evans1, Asli Altaykan, Sedef Sahin

  • 1Department of Dermatology, Hacettepe University Faculty of Medicine, Ankara, Turkey. sevans@hacettepe.edu.tr

Pediatric Dermatology
|December 11, 2008
PubMed
Summary

Phototherapy is a safe and effective treatment for childhood skin conditions like psoriasis and pityriasis lichenoides. This study shows high response rates in pediatric patients, with minimal side effects.

Area of Science:

  • Pediatric Dermatology
  • Phototherapy Research
  • Dermatological Treatments

Background:

  • Limited data exists on phototherapy's efficacy for childhood skin diseases.
  • Phototherapy is a treatment modality used for various dermatological conditions.

Purpose of the Study:

  • To evaluate the efficacy and safety of phototherapy in pediatric patients.
  • To report clinical experience with phototherapy in children and adolescents.

Main Methods:

  • Retrospective data collection from pediatric patients treated between 1985 and 2005.
  • Analysis of treatment outcomes for conditions including psoriasis, vitiligo, pityriasis lichenoides, and alopecia areata.
  • Commonly administered treatments included narrow-band ultraviolet-B and ultraviolet-B.

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

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Published on: July 11, 2013

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06:24

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Published on: May 28, 2013

An In Vitro Approach to Photodynamic Therapy
04:53

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Published on: August 17, 2018

Main Results:

  • High response rates were observed: 92.9% for psoriasis with narrow-band ultraviolet-B, and 100% for pityriasis lichenoides chronica with narrow-band ultraviolet-B.
  • Vitiligo showed a 57% response to psoralen plus ultraviolet-A, and alopecia areata had a 20% response to psoralen plus ultraviolet-A.
  • Erythema was the most frequent adverse effect, indicating good tolerability.

Conclusions:

  • Phototherapy is a well-tolerated and effective treatment for childhood dermatoses.
  • It is particularly efficacious for pediatric psoriasis and pityriasis lichenoides chronica.
  • The findings support the use of phototherapy in managing specific skin conditions in children.