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Characterization of BK channel splice variants using membrane potential dyes

F Saleem1, I C M Rowe, M J Shipston

  • 1Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK.

British Journal of Pharmacology
|December 11, 2008
PubMed
Summary

Large conductance calcium- and voltage-activated potassium (BK) channels have splice variants with differing sensitivities to calcium. The BK channel blocker paxilline effectively inhibits all variants, making it useful for functional assays.

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