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Related Experiment Video

Updated: Jun 27, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Allergy and autoimmune disease: a registry-based study.

B Lindelöf¹, F Granath, M Tengvall-Linder

¹Dermatology and Venereology, The Children's Hospital at Westmead, Sydney, Australia. bernt.lindelof@karolinska.se

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology

|December 11, 2008

Summary

This study found that having allergies, indicated by a positive Phadiatop test, is weakly linked to a lower risk of developing autoimmune diseases. However, highly elevated total serum IgE levels were associated with an increased risk of subsequent autoimmune disease.

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Last Updated: Jun 27, 2026

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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

Immunology
Epidemiology
Autoimmune Diseases

Background:

Allergy and autoimmunity are distinct immune system dysregulations.
The relationship between allergy and autoimmunity is not well understood, with conflicting hypotheses.
Previous studies have reported both positive and negative associations between allergy and autoimmune conditions.

Purpose of the Study:

To investigate the association between allergic disease and the subsequent risk of autoimmune diseases.
To conduct a large-scale epidemiological study using a defined allergic disease cohort.
To clarify the relationship between allergy and autoimmunity.

Main Methods:

A cohort of 68,770 subjects tested for total serum IgE and 72,228 for allergic disease (Phadiatop) between 1990-2002 at Karolinska University Hospital, Stockholm.
Linking the allergy cohort with the Swedish Inpatient Registry (1968-2004) to track diagnoses of 28 autoimmune diseases.
Utilizing Cox and logistic regression models to estimate the risk of autoimmune diseases in allergy-tested individuals.

Main Results:

A positive Phadiatop test for allergy was associated with a statistically decreased risk of subsequent autoimmune disease (HR: 0.80, 95% CI: 0.68-0.94).
Prior autoimmune disease showed a decreased risk of a positive Phadiatop test (OR: 0.83, 95% CI: 0.72-0.96).
Highly elevated total serum IgE levels correlated with an increased risk of subsequent autoimmune disease (HR: 1.36, 95% CI: 1.09-1.70).

Conclusions:

The findings support a potential inverse relationship between allergy (defined by Phadiatop) and autoimmune disease.
This association between allergy and autoimmune disease risk appears to be weak.
Elevated total IgE levels, however, suggest a potential increased risk for autoimmune conditions.