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Updated: Jun 27, 2026
08:06
Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
Published on: January 15, 2010
Behavioral and movement disorders induced by local inhibitory dysfunction in primate striatum
Yulia Worbe1, Nicolas Baup, David Grabli
1Institut National de la Santé et de la Recherche Médicale, Unité 679, Paris F-75013, France.
Cerebral Cortex (New York, N.Y. : 1991)
|December 11, 2008
Summary
Researchers found that disrupting specific areas of the striatum in monkeys caused abnormal movements and behaviors. This suggests localized neuronal dysfunction in the basal ganglia may underlie various neurological and psychiatric disorders.
Area of Science:
- Neuroscience
- Behavioral Neurology
Background:
- The basal ganglia are functionally divided into sensorimotor, associative, and limbic territories.
- Previous studies showed neuronal dysfunction in the globus pallidus causes different behaviors based on functional territory.
Purpose of the Study:
- To investigate the effects of localized neuronal dysfunction in the striatum on behavior.
- To extend previous findings on basal ganglia functional territories.
Main Methods:
- Bicuculline microinjections were performed into different functional territories of the striatum in 6 monkeys.
- Neuronal activity was recorded near microinjection sites.
Main Results:
- Microinjections into sensorimotor (posterior putamen) and associative (dorsal anterior striatum) territories induced abnormal movements.
- The limbic territory (ventral striatum) showed 3 subregions associated with different abnormal behaviors.
- Bicuculline caused focal neuronal hyperactivity surrounded by hypoactivity.
Conclusions:
- Specific striatal regions are involved in movement and a spectrum of behavioral disorders.
- Local inhibitory dysfunction in the striatum may be a pathological mechanism for neurological and psychiatric disorders.
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