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Updated: Jun 27, 2026
09:37
Preparation of Fungal and Plant Materials for Structural Elucidation Using Dynamic Nuclear Polarization Solid-State NMR
Published on: February 12, 2019
[Structure and function of fungal cell wall].
1Tokyo University of Pharmacy and Life Sciences.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 17, 2008
Summary
Fungal cell wall polysaccharides like beta-glucan and mannan have unique properties and diverse biological activities. Research into these complex fungal glycans is challenging but crucial for understanding their roles.
Area of Science:
- Mycology
- Carbohydrate Chemistry
- Immunology
Context:
- Fungal cell walls are complex networks of polysaccharides, including beta-glucans, mannans, alpha-glucans, and chitin.
- These fungal glycans are structurally distinct from human and animal polysaccharides.
- Their insolubility and complex composition present significant research challenges.
Purpose:
- To review the diverse cell wall glycans produced by fungi and yeasts.
- To highlight the extensive research on beta-glucans, covering their chemistry, biological activity, and clinical applications.
- To summarize studies on mannan immunotoxicity and mention alpha-glucan, chitin, and capsular polysaccharides.
Summary:
- Fungi and yeasts synthesize a variety of cell wall polysaccharides, forming intricate networks with other components.
- Beta-glucans have been studied extensively, encompassing their chemical properties, biological functions, and therapeutic potential.
- Mannans are primarily investigated for their immunotoxic effects, while other glycans like alpha-glucan and chitin are noted for their structural and genetic aspects.
Impact:
- Understanding fungal glycans is key to developing targeted antifungal therapies.
- This review provides a comprehensive overview of fungal polysaccharide research, aiding future investigations.
- Characteristic properties of fungal polysaccharides offer potential for novel biotechnological and medical applications.
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