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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

[Clinical efficacies of antifungal injections]

Yumi Fujii1, Naohiko Inase, Yasuyuki Yoshizawa

  • 1Department of Integrated Pulmonology, Tokyo Medical and Dental University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 17, 2008
PubMed

Insights

The incidence of fungal infections is rising, prompting the approval of new antifungal drugs like liposomal amphotericin B, voriconazole, and micafungin for improved patient therapy.

Area of Science:

  • Medical Mycology
  • Pharmacology
  • Infectious Diseases

Background:

  • Fungal infections are increasing globally.
  • Amphotericin B has long been the standard antifungal treatment.
  • Novel antifungal agents are emerging to address limitations of older therapies.

Purpose of the Study:

  • To review the clinical benefits of newly approved antifungal agents in Japan.
  • To discuss the potential for individualized antifungal therapy.
  • To highlight the need for establishing new treatment standards.

Main Methods:

  • Review of recent clinical data and regulatory approvals in Japan.
  • Comparative analysis of novel antifungal agents (liposomal amphotericin B, voriconazole, micafungin).
  • Discussion of pharmacological properties and toxicological profiles.

Main Results:

  • Liposomal amphotericin B offers reduced toxicity compared to conventional amphotericin B.
  • Voriconazole is recommended for invasive aspergillosis treatment.
  • Micafungin represents a new class of antifungal agents (echinocandins).

Conclusions:

  • New antifungal agents provide options for more effective, individualized patient care.
  • These advancements necessitate the establishment of updated standard antifungal therapies.
  • Continued research is crucial for optimizing treatment strategies against invasive fungal infections.

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