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Published on: April 7, 2023
[Effect of bovine colostrum protein on rat bone mineral density]
Ming Du1, Cong Wang, Lanwei Zhang
1College of Food Science & Engineering, Harbin Institute of Technology, Harbin 150090, China. duming121@163.com
Objective:
To investigate the effect of bovine colostrum protein (BCP) on bone mineral density (BMD) in ovariectomized (ovx) rats.
Methods:
48 female Sprague-Dawley rats of clean grade were ovariectomized and another 12 rats received a sham operation. The ovx rats were randomly separated into 4 groups: ovx control, ovx low-does, ovx media dose, and ovx high-dose. BCP at the doses of 0.20, 1.00 and 2.00 g/(kg bw x d) were applied in rat diet, and the rats were gavaged once per day for 12 weeks. BMD (at proximal, middle of diaphysis, and distal end) was measured by dual energy X-ray absorptiomery, and the body weight, length and weight of thighbone were measured also.
Results:
The bone density, bone weight, bone weight/length and bone weight/body weight in all dosages BCP groups were significantly higher than those in ovx groups.
Conclusion:
BCP at the dose of 0.20 g/(kg bw x d) increase femur bone density at proximal and middle segment, and distal end in ovx rat.
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