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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

Updated: Jun 27, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Ischaemic colitis--review.

I Dimitrijević1, M Micev, Dj Saranović

  • 1First Surgical Clinic, Clinical Centre of Serbia, Belgrade.

Acta Chirurgica Iugoslavica
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Ischaemic colitis, the most common intestinal ischaemia, presents with abdominal pain and bloody diarrhea. Diagnosis is often via colonoscopy, with management depending on whether it is non-gangrenous or gangrenous.

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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Area of Science:

  • Gastroenterology
  • Vascular Medicine

Background:

  • Colonic ischaemia, or ischaemic colitis, is the predominant form of intestinal ischaemia.
  • It was first described by Marston in 1966, with patterns including reversible injury, ulcers with stricturing, and gangrene.
  • Vulnerable anatomical areas include Griffith's point and Sudeck's critical point.

Purpose of the Study:

  • To outline the classification, presentation, and management of ischaemic colitis.
  • To differentiate between non-gangrenous and gangrenous forms of the condition.
  • To define surgical indications for severe cases.

Main Methods:

  • Review of clinical presentation and diagnostic methods.
  • Classification based on injury patterns and clinical outcomes.
  • Analysis of indications for surgical intervention.

Main Results:

  • Ischaemic colitis presents with abdominal pain, vomiting, bloody diarrhea, and hematochezia, often with subtle examination findings.
  • Colonoscopy is the primary diagnostic tool.
  • Non-gangrenous colitis (80-85% of cases) involves mucosa/submucosa; gangrenous colitis (15-20%) involves transmural infarction, potentially leading to necrosis.

Conclusions:

  • Ischaemic colitis classification includes transient reversible, chronic non-reversible, and gangrenous forms.
  • Management strategies are guided by the severity and type of ischaemia.
  • Surgical intervention is reserved for specific complications like perforation, sepsis, or refractory disease.