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Updated: Jan 9, 2026
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Predictors of a response to radioactive iodine therapy in hyperthyroidism - ablative dose concept: A 23-year single
N Pantic1, J Petrovic2, S Odalovic2
1Center for Nuclear Medicine with PET, University Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia.
Objective:
The three treatment modalities for patients with hyperthyroidism are antithyroid drugs (ATDs), surgery, and radioactive iodine (RAI) therapy. The study aims to determine the predictors of a response to RAI in patients with hyperthyroidism.
Materials And Methods:
We retrospectively assessed 914 patients who received RAI for the treatment of hyperthyroidism between January 2000 and December 2023, with a follow-up of at least 6 months after the first dose.
Results:
Hypothyroidism was ultimately achieved in 62.9% of the patients. Multiple variables are possible predictors in univariable logistic regression analysis. However, only shorter duration of ATD therapy (odds ratio 0.996; 95% confidence interval [CI], 0.093-0.999; P=.003, multivariable logistic regression analysis) and a diagnosis of Graves' disease (GD) (odds ratio 1.803; 95% confidence interval [CI], 1.042-3.141; P=.035, multivariable logistic regression analysis) are the independent predictors of post-treatment hypothyroidism, with decreasing age also being a late-response independent predictor of hypothyroidism 24 months after the treatment (odds ratio 0.983; 95% confidence interval [CI], 0.968-0.998; P=.028, multivariable logistic regression analysis). The median time to hypothyroidism was 10.0±0.7 months (Kaplan-Meier method), with a statistically significant difference in hypothyroidism-free survival (HFS) between patients with GD on one side and solitary toxic adenoma (STA) and toxic multinodular goiter (TMG) on the other (P<.001, log-rank test).
Conclusions:
GD and a shorter duration of previous ATD therapy are independent predictors of post-therapeutic hypothyroidism in patients treated for hyperthyroidism with RAI, with younger age also being an independent predictor of a late response.
