Related Experiment Video
Updated: Jun 27, 2026
07:41
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
[The metastatic cascade: angiogenesis and new concepts]
1Service d'Urologie, Université Paris Descartes, France. arnaud.mejean@nck.aphp.fr
Summary
Metastatic progression involves a series of organized steps, known as the metastatic cascade, including angiogenesis and epithelial mesenchymal transition. Understanding these steps and the tumor microenvironment is crucial for controlling cancer spread.
Area of Science:
- Oncology
- Cell Biology
- Cancer Research
Context:
- Metastatic progression is a complex, multi-step process crucial for cancer spread.
- Key events include angiogenesis, epithelial mesenchymal transition, and the formation of premetastatic niches.
- Tumor microenvironment and genetic factors significantly influence tumor progression.
Purpose:
- To elucidate the organized steps of the metastatic cascade.
- To highlight the roles of angiogenesis, epithelial mesenchymal transition, and the premetastatic niche.
- To emphasize the interplay between genetic factors and the tumor microenvironment in cancer metastasis.
Summary:
- Metastatic progression occurs through a series of well-defined steps termed the metastatic cascade.
- Angiogenesis, epithelial mesenchymal transition, premetastatic niche formation, and metastatic signature theory are key components.
- The process is influenced by both intrinsic genetic factors and extrinsic elements like the tumor microenvironment, as suggested by the 'seed and soil' theory.
Impact:
- Provides a clearer understanding of the mechanisms driving cancer metastasis.
- Identifies critical steps and factors that could be targeted for therapeutic intervention.
- Enhances knowledge of how tumor cells interact with their microenvironment to colonize distant organs.
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