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Updated: Jun 27, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

[Metastases from urothelial carcinoma : future and prospects]

T Lebret1, A Méjean

  • 1Service d'Urologie, Hôpital Foch, Faculté de médecine Paris-Ile-de-France-Ouest, UVSQ, France. t.lebret@hopital-foch.org

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|December 17, 2008
PubMed

Insights

Bladder cancer remains challenging, especially metastatic disease, despite cisplatin chemotherapy. New anti-angiogenic drugs and targeted therapies offer promising avenues for individualized urothelial carcinoma treatment.

Area of Science:

  • Uro-oncology
  • Medical oncology
  • Cancer research

Context:

  • Bladder cancer exhibits chemosensitivity, but metastatic lesions yield poor outcomes.
  • Cisplatin-based chemotherapy is the current standard treatment for metastatic bladder cancer.
  • Emerging anti-angiogenic drugs and targeted therapies are being investigated for urothelial carcinoma.

Purpose:

  • To explore novel therapeutic strategies for metastatic bladder cancer.
  • To investigate the potential of anti-angiogenic drugs in urothelial carcinoma.
  • To highlight the growing interest in individualized treatment approaches for bladder cancer.

Summary:

  • Despite being chemosensitive, bladder cancer with metastatic lesions has poor prognosis.
  • Cisplatin-based chemotherapies remain the primary treatment modality.
  • New molecules, particularly anti-angiogenic drugs, are being tested, alongside individualized treatments based on molecular factors and targeted therapy.

Impact:

  • Advances in understanding and treating metastatic bladder cancer.
  • Potential for improved patient outcomes through novel therapeutic strategies.
  • Shift towards personalized medicine in urothelial carcinoma management.

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