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Updated: Jun 27, 2026

06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
[Angiogenesis: the renal cancer model]
1Service d'Urologie, Université Paris Descartes, France. arnaud.mejean@nck.aphp.fr
Abstract:
VHL gene inactivation, involved in the majority of metastatic non inherited renal carcinoma, I responsible of HIF accumulation. HIF leads to the activation of numerous genes including VEGF and PDGF. VEGF binds to his receptors present on endothelial cells to promote tumoral angiogenesis. Targeted therapy inhibit tumoral blood vessels growth and involves probably others complex mechanisms.

