[The natural history of metastatic prostate cancer]

Prostate cancer is a pathology which progress with successive stages directly dependant on hormonosensitivity. When metastasis occur, cell modifications and biologic transformations lead to disease diffusion. PSA is useful to practically follow the evolution of the prostate cancer but it is probably the molecular biology which probably will be necessary to get prognostic and predictive markers of metastasis power. At each step of the metastatic cascade, it is possible to imagine a specific targeted therapy for this disease which is today non curable.