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Updated: Jun 27, 2026
Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
A novel sol-gel-material prepared by a surface imprinting technique for the selective solid-phase extraction of
Xiaoman Jiang1, Wei Tian, Chuande Zhao
1College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Tianshui Road 222, Lanzhou 730000, PR China.
Abstract:
A novel and simple imprinted amino-functionalized silica gel material was synthesized by combining a surface molecular imprinting technique with a sol-gel process on the supporter of activated silica gel for solid-phase extraction-high performance liquid chromatography (SPE-HPLC) determination of bisphenol A (BPA). Non-imprinted silica sorbent was synthesized without the addition of BPA using the same procedure as that of BPA-imprinted silica sorbent. The BPA-imprinted silica sorbent and non-imprinted silica sorbent were characterized by FT-IR and the static adsorption experiments. The prepared BPA-imprinted silica sorbent showed high adsorption capacity, significant selectivity and good site accessibility for BPA. The maximum static adsorption capacity of the BPA-imprinted and non-imprinted silica sorbent for BPA was 68.9 and 34.0mgg(-1), respectively. The relatively selective factor value of this BPA-imprinted silica sorbent was 4.5. Furthermore, the difference of the retention characteristics of BPA on the C(8) SPE column and BPA-imprinted silica SPE (MIP-SPE) was compared. The MIP-SPE-HPLC method showed higher selectivity to BPA than the traditional SPE-HPLC method. At last, the BPA-imprinted polymers were used as the sorbent in solid-phase extraction to determine BPA in water samples with satisfactory recovery higher than 99% (R.S.D. 3.7%).
