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Near-infrared spectroscopy applications in pharmaceutical analysis.

J Luypaert¹, D L Massart, Y Vander Heyden

¹Department of Analytical Chemistry and Pharmaceutical Technology, Pharmaceutical Institute, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussel, Belgium.

|December 17, 2008

Summary

Near-infrared (NIR) spectroscopy is a versatile, non-destructive technique. This review highlights its pharmaceutical applications, from raw material analysis to final product release, including process analytical technology (PAT) and NIR imaging.

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Area of Science:

Analytical Chemistry
Spectroscopy
Pharmaceutical Science

Background:

Near-infrared (NIR) spectroscopy is a rapid, non-destructive analytical method.
It offers significant advantages across various industrial sectors.
Its utility in pharmaceuticals spans quality control and process monitoring.

Purpose of the Study:

To review recent advancements in pharmaceutical applications of NIR spectroscopy.
To explore NIR spectroscopy's role in process analytical technology (PAT).
To discuss emerging applications in NIR imaging within the pharmaceutical industry.

Main Methods:

Literature review of recent developments in NIR spectroscopy for pharmaceuticals.
Categorization of applications into identification, water content, assay, and other areas.
Discussion of instrumental advancements enabling new applications.

Main Results:

NIR spectroscopy is applicable from raw material identification to final product release.
Its characteristics facilitate implementation as a process analytical technology (PAT).
Recent instrumental progress expands possibilities in NIR imaging.

Conclusions:

NIR spectroscopy is a valuable tool for pharmaceutical analysis and quality control.
The technique supports real-time process monitoring and product release.
NIR imaging presents promising future applications in pharmaceutical development and manufacturing.