Related Experiment Video
Updated: Jun 27, 2026
Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
Testing the validity of microwave-interfaced, in situ Raman spectroscopy as a tool for kinetic studies
Jason R Schmink1, Jennifer L Holcomb, Nicholas E Leadbeater
1Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, USA.
Abstract:
Raman spectroscopy in conjunction with microwave heating is a convenient and robust tool for monitoring organic reactions from a qualitative perspective. Its validity as a method for obtaining quantitative data is shown. Activation enthalpies for the synthesis of a range of substituted chalcones are determined and the results compared with well-established previous data and reactivity trends for this aldol condensation. The methodology is used for obtaining previously unreported pK(a) data for substituted acetophenones.
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