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Toward the total synthesis of the brasilinolides: stereocontrolled assembly of a C1-C19 polyol segment
Ian Paterson1, Friedrich A Mühlthau, Christopher J Cordier
1University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk
Abstract:
Two highly convergent syntheses of a fully protected C1-C19 polyol subunit of the brasilinolide family of immunosuppressive macrolides are described, exploiting boron-mediated 1,5-anti aldol couplings to form the C8-C9 and C13-C14 bonds.
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