Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of the cf-MMSP assay for enhanced analytical sensitivity of methylated DNA in breast cancer liquid biopsy.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

CRYβB2 is a biomarker for poor prognosis and response to CDK4/6 inhibitors in breast cancer.

Breast cancer research : BCR·2026
Same author

Correction: Hypermethylation of 14-3-3 σ (stratifin) is an early event in breast cancer.

Oncogene·2025
Same author

Evaluating DNA Methylation in Random Fine Needle Aspirates from the Breast to Inform Cancer Risk.

The breast journal·2025
Same author

Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries.

Clinical epigenetics·2024
Same author

Nanoparticle-Based Combination Therapy Enhances Fulvestrant Efficacy and Overcomes Tumor Resistance in ER-Positive Breast Cancer.

Cancer research·2023

Related Experiment Video

Updated: Jun 27, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Epigenomics and breast cancer.

Pang-Kuo Lo1, Saraswati Sukumar

  • 1Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI-143, Baltimore, MD 21231, USA.

Pharmacogenomics
|December 17, 2008
PubMed
Summary

Epigenetic alterations in breast cells drive cancer development and drug resistance. Understanding these epigenetic changes offers new diagnostic and therapeutic strategies for breast cancer.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Breast cancer arises from genetic and epigenetic alterations affecting gene function.
  • Epigenomics advances understanding of breast cancer mechanisms, impacting diagnosis and treatment.
  • Epigenetic regulation involves DNA methylation, histone modifications, and nucleosomal remodeling, controlling gene expression via chromatin structure.

Purpose of the Study:

  • To review the roles of epigenetic machinery in breast cancer development and recurrence.
  • To highlight epigenetic alterations as predictive biomarkers.
  • To explore epigenetic alterations as novel targets for anticancer therapy.

Main Methods:

  • Literature review of epigenetic mechanisms in breast cancer.
  • Analysis of epigenetic alterations in gene expression.

Related Experiment Videos

Last Updated: Jun 27, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

  • Evaluation of epigenetic biomarkers and therapeutic targets.

    • Main Results:

    • Aberrant epigenetic regulation contributes to breast cancer initiation, promotion, and maintenance.
    • Epigenetic changes are implicated in the development of drug resistance in breast cancer.
    • Epigenetic alterations are significant in breast cancer recurrence.

    Conclusions:

    • Epigenetic machinery plays a critical role in breast cancer progression and recurrence.
    • Epigenetic alterations serve as valuable predictive biomarkers for breast cancer.
    • Targeting epigenetic modifications presents a promising avenue for novel breast cancer therapies.