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Updated: Jun 27, 2026

Purification of the Dendritic Filopodia-rich Fraction
Published on: May 2, 2019
Presenilin: RIP and beyond
Matthew R Hass1, Chihiro Sato, Raphael Kopan
1Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, United States.
Abstract:
Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis.
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