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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell

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Related Experiment Video

Updated: Jun 27, 2026

Screening for Phytoestrogens using a Cell-based Estrogen Receptor &#946; Reporter Assay
06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

[Advances on progesterone receptor gene].

Bao-Yun Zhang1, Ran DI, Ming-Xing Chu

  • 1Bioengineering Institute of Chongqing University, Chongqing 400030, China. zhangbaoyun418@sina.com

Yi Chuan = Hereditas
|December 17, 2008
PubMed
Summary

Progesterone is vital for female reproduction, acting through progesterone receptors (PGR-A and PGR-B). This review covers the progesterone receptor gene

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Molecular genetics

Context:

  • Progesterone is a critical steroid hormone influencing female reproductive processes.
  • The actions of progesterone are primarily mediated by its receptors, PGR-A and PGR-B.
  • Understanding the progesterone receptor gene is essential for reproductive health.

Purpose:

  • To review the structure, expression regulation, and genetic polymorphism of the progesterone receptor gene.
  • To explore the intricate relationship between the progesterone receptor gene and mammalian reproductive function.

Summary:

  • This review details the structure and genetic variations (polymorphism) of the progesterone receptor gene.
  • It examines how the expression of this gene is regulated.

Related Experiment Videos

Last Updated: Jun 27, 2026

Screening for Phytoestrogens using a Cell-based Estrogen Receptor &#946; Reporter Assay
06:07

Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay

Published on: June 7, 2020

  • The functional link between the progesterone receptor gene and reproductive capabilities in mammals is discussed.

    • Impact:

    • Provides a comprehensive overview of the progesterone receptor gene.
    • Highlights the significance of progesterone receptor gene in reproductive biology.
    • Serves as a foundational resource for researchers in endocrinology and reproductive medicine.